Soy Supplements May Not Shield Against Breast Cancer (HealthDay)

FRIDAY, Feb. 3 (HealthDay News) -- Soy supplements do not protect women against breast cancer, a new study suggests.

The findings are consistent with the results of previous studies that examined the cancer prevention benefits of the dietary supplements, said lead researcher Dr. Seema Khan, a professor of surgery at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

The study included 98 women who were randomly assigned to receive a mixed soy isoflavones supplement or placebo. Isoflavones are components of soy foods thought to have anti-estrogen activity (estrogen is "fuel" for many breast cancers).

After six months, the researchers examined levels of Ki-67 -- a protein marker of cancer cell growth -- in certain breast cancer cells taken from the women. Overall, there were no differences in Ki-67 levels between women who took the soy supplement and those who took the placebo.

However, the level of Ki-67 increased from 1.71 to 2.18 in premenopausal women taking the soy supplement, which suggests the supplement might even have a negative effect, according to the study published in February issue of the journal Cancer Prevention Research.

"This was a small finding," Khan stressed in a news release from the American Association for Cancer Research, "but one that should suggest caution."

"Simply put, supplements are not food. Although soy-based foods appear to have a protective effect, we are not seeing the same effect with supplementation using isolated components of soy, so the continued testing of soy supplements is likely not worthwhile," Kahn concluded.

But one expert said the study, while valuable, had limitations.

Dr. Patrick Borgen, director of Breast Cancer Care Services at the Maimonides Cancer Center in New York City, called the study "thought provoking and well-executed."

But he added that uncertainties remain. For example, the area of the breast from which the cells were taken and studied matters, because cancer develops in different ways across the geography of the breast. Furthermore, other potential risk factors, such as diet, exercise, alcohol intake and stress, could play a role in the women's breast cancer risk as well and "are extremely hard to control for in this kind of study," Borgen said.

Finally, Borgen said, it is still difficult to predict the "long-term consequences" of the cell changes captured by Ki-67 testing.

For all of those reasons, "the conclusions -- that further study may not be warranted or that use of these supplements in premenopausal women may be dangerous -- should therefore be taken in the context of the limitations of the study," Borgen said.

More information

The U.S. National Library of Medicine has more about soy.

Source: http://us.rd.yahoo.com/dailynews/rss/health/*http%3A//news.yahoo.com/s/hsn/20120203/hl_hsn/soysupplementsmaynotshieldagainstbreastcancer

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Estate Planning for Your Online Life | Arizona Wills & Trusts

Bankrate.com:? Life in the digital age is both easier and more complicated. The same is true when it comes to estate planning. Not too long ago, a physical safety deposit box at the bank was all it took to safeguard important financial documents. Now, much of that information is online and guarded by numerous passwords ? setting up a potential mess for heirs to sort through.

At death, a person?s estate goes through the probate process and can?t legally be accessed until an executor is named, according to Leanna Hamill, a Massachusetts estate-planning and elder-law attorney. However, things get more complicated if you become incapacitated because someone will need entry to your financial life ? online and on paper ? to make sure things run smoothly when you can?t.

?Everything?s getting more electronic these days,? says Leslie Corcoran, CFP and founder of Family First Financial Planning in Florida. The Internet has made more financial options available for estate planning, and attorneys often store wills and trusts online. This means information and accounts could be scattered across the digital universe. ?I have clients who have CDs all over the place,? says Corcoran, adding that when someone dies or becomes incapacitated, if you don?t know what they have, ?you?ll have to go through every piece of documentation and pray they were organized.?

Continue reading about Estate Planning for Your Online Life.

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Source: http://www.keytlaw.com/arizonawills/2012/02/estate-planning-for-your-online-life/

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Why red wine can be healthy: Probable mechanism underlying resveratrol activity uncovered

ScienceDaily (Feb. 2, 2012) ? National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits. The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging. Rather, the authors found that resveratrol inhibits certain types of proteins known as phosphodiesterases (PDEs), enzymes that help regulate cell energy.

These findings may help settle the debate regarding resveratrol's biochemistry and pave the way for resveratrol-based medicines. The chemical has received significant interest from pharmaceutical companies for its potential to combat diabetes, inflammation, and cancer. The study appears in the Feb. 3 issue of Cell.

"Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease, and heart disease," said lead study author Jay H. Chung, M.D., Ph.D., chief of the Laboratory of Obesity and Aging Research at the NIH's National Heart, Lung, and Blood Institute. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells."

Several previous studies suggested that resveratrol's primary target is sirtuin 1. Chung and colleagues suspected otherwise when they found that resveratrol activity required another protein called AMPK. This would not be the case if resveratrol directly interacted with sirtuin 1.

In this study, the researchers methodically traced out the metabolic activity in cells treated with resveratrol and identified PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol. By inhibiting PDE4, resveratrol triggers a series of events in a cell, one of which indirectly activates sirtuin 1.

To confirm that resveratrol attaches to and inhibits PDE proteins, Chung's group gave mice rolipram, a drug known to inhibit PDE4. Rolipram reproduced all of the biochemical effects and health benefits of resveratrol, such as preventing diet-induced obesity, improving glucose tolerance, and increasing physical endurance.

Chung noted that because resveratrol in its natural form interacts with many proteins, not just PDEs, it may cause not-yet-known toxicities as a medicine, particularly with long-term use.

He added that the levels of resveratrol found in wine or foods are likely not high enough to produce significant health benefits or problems. Convincing clinical studies in humans have used about 1 gm of resveratrol per day, roughly equal to the amount found in 667 bottles of red wine.

The study results also suggest that inhibitors of PDE4 may offer the benefits of resveratrol without the potential toxicities arising from resveratrol's interactions with other proteins. One PDE4 inhibitor called roflumilast has already been approved by the FDA for the treatment of COPD (chronic obstructive pulmonary disease).

"This result underscores the need for careful, well-controlled studies to illuminate how these natural products operate," said Robert Balaban, Ph.D., director of the NHLBI Division of Intramural Research. "As Dr. Chung's work suggests, the effects of resveratrol seem to be more complicated than originally thought. However, this new insight into the phosphodiesterases might prove an interesting avenue to pursue."

In addition to Dr. Chung's lab at the NHLBI, other contributors to this study included collaborators in the Cardiovascular Pulmonary Branch of the NHLBI; the University of California, Davis; the University of North Carolina, Chapel Hill; University of Texas Southwestern Medical Center, Dallas; Sun Yat-sen University, Guangzhou, China; University Medical Center, Utrecht, The Netherlands; and Emerald BioStructures, Bainbridge Island, Wash.

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The above story is reprinted from materials provided by NIH/National Heart, Lung and Blood Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra?L. Brown, Myung?K. Kim, Michael?A. Beaven, Alex?B. Burgin, Vincent Manganiello, Jay?H. Chung. Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases. Cell, 2012; 148 (3): 421 DOI: 10.1016/j.cell.2012.01.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/02/120202151133.htm

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Westward, Ho: Romney, GOP rivals now spreading out

Republican presidential candidate, former Massachusetts Gov. Mitt Romney greets supporters at a campaign rally in Eagan, Minn., Wednesday, Feb. 1, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney greets supporters at a campaign rally in Eagan, Minn., Wednesday, Feb. 1, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former House Speaker Newt Gingrich shakes hands during a campaign stop at the Great Basin Brewing Co. Wednesday, Feb. 1, 2012, in Reno, Nev. (AP Photo/Evan Vucci)

Republican presidential candidate Mitt Romney left, hands 6-month-old Dexter Hall of Plymouth, Minn. back to his mother, Laura, during a campaign stop at Freightmasters, Inc. in Eagan, Minn., on Wednesday, Feb. 1, 2012. Romney, who won big in Florida with a barrage of negative ads, predicted the tone of the GOP campaign was "just a precursor to what you'll see" from President Barack Obama in the general election. And he said voters paid more attention to what they heard in the campaign debates than whatever ads were flooding the airwaves. (AP Photo/The St. Paul Pioneer Press, Ben Garvin ) MINNEAPOLIS STAR TRIBUNE OUT

A Reno police officer looks over a crowd as Republican presidential candidate former House Speaker Newt Gingrich makes a campaign stop at the Great Basin Brewing Co. on Wednesday, Feb. 1, 2012, in Reno, Nev. (AP Photo/Evan Vucci)

Republican presidential candidate, former Pennsylvania Sen. Rick Santorum greets students during a campaign stop, Wednesday, Feb 1, 2012, at Colorado Christian University in Lakewood, Colo. (AP Photo/Ed Andrieski)

WASHINGTON (AP) ? The Republican presidential campaign rolled westward Wednesday, Mitt Romney riding herd after his Florida primary victory, Newt Gingrich looking for a new stake and a top party leader insisting the long trail won't necessarily hurt the GOP in the race against President Barack Obama.

Already the television ads were showing up in states that vote next, caucuses in Nevada on Saturday, in Minnesota and Colorado next Tuesday and in Maine the following weekend.

"I'm feeling like we've got a good pathway ahead," Romney declared in a television interview on the day after his Florida triumph.

He is favored in Nevada, where there are 28 Republican National Convention delegates at stake. And, alone among the contenders, appears to have the money to compete aggressively in all the other states as well.

Gingrich decamped from Florida but with prospects considerably dimmer than Romney's.

He was conceding nothing. Routed on Tuesday night, the former House speaker vowed to stay in the race until the party convention next summer. And his decision not to telephone the primary winner with congratulations drew notice.

"I guess Speaker Gingrich doesn't have our phone number," Romney said.

The Florida campaign was marked by millions of dollars in negative ads, and Gingrich's promise to remain in the race raised the prospect of a months-long struggle. But current House Speaker John Boehner said he was not concerned.,

"I would remind people that President Obama and Secretary of State Hillary Clinton had a fight that went through June of 2008. I think everybody just needs to realize that this will resolve itself," he said.

Jubilant in victory on Tuesday night, Romney was thrown onto the defensive the day after. "I'm not concerned about the very poor" because they have a social safety net, he said on CNN. Criticized quickly, he hastened to clarify.

"No, no, no, no, no, no, no," Romney told reporters on his campaign plane when asked about the comments. He referred back to his complete remarks, in which he had said he would focus on middle-income Americans rather than the very poor, who get government help, or the very rich, who don't need it. "My energy is going to be devoted to helping middle-income people," he said.

By then, though, he was drawing criticism from conservatives who worried he was showing a penchant for verbal gaffes as well as from Obama's campaign manager. "So much for 'we're all in this together,'" tweeted Jim Messina.

Gingrich piled on. " I am fed up with politicians in either party dividing Americans against each other," he said.

After making no significant campaign effort in Florida, former Sen. Rick Santorum and Texas Rep. Ron Paul looked for better days in the contests just ahead.

Santorum picked up an endorsement from former Colorado Rep. Tom Tancredo, known for his hardline position on immigration.

Eager to emerge as the leading conservative in the race, Santorum said Gingrich was nearing the end of his run. "If Newt's out of the race, all his votes come to me," he said, mirroring what the former House speaker frequently says about him.

In a speech in Woodland Park, Colo., Santorum said Romney's nomination would doom the party to defeat in the fall.

"Barack Obama, in a debate or in this election, is going to destroy Mitt Romney on the issue of health care," Santorum warned, saying that the former governor supported a requirement for individuals to purchase health care in Massachusetts that is akin to the provision in the legislation that Obama signed into federal law.

Paul, campaigning in Las Vegas, said he favors an immigration policy that doesn't rely on "barbed wire fences and guns on the border." Appearing before an audience of Hispanics, he said he opposes illegal immigration but also is against any effort to round up and deport individuals who are in the United States illegally.

After a month in which four contests produced three winners, Romney appeared to hold formidable advantages in fundraising and organization to go with a lead in national convention delegates. After winning all 50 at stake in Florida, he had 87 in AP's count. Gingrich had 26 delegates, Rick Santorum had 14 and Ron Paul had four. It takes 1,144 to win the nomination.

Reports filed with the Federal Election Commission show Romney's campaign had $20 million on hand as of Jan. 1 and Restore Our Future, an outside group that supports him, had $23.6 million.

The total of $43.6 million dwarfs figures reported by the other contenders and the groups that back them, although the onset of the 2012 caucuses and primaries was certain to have produced changes.

Figures from Florida show Romney and Restore Our Future spent more than $15 million on television ads combined, many of which attacked Gingrich. The former speaker and an organization that backs him spent less than $4 million.

Already, Romney and Restore our Future were airing ads in Nevada, as was Paul.

Paul also was on the air in Minnesota, along with the Red White and Blue Fund, which support Santorum.

___

Associated Press writers Philip Elliott and Beth Fouhy in Colorado, Kasie Hunt in Minnesota, Laurie Kellman in Washington and Shannon McCaffrey in Nevada contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-01-US-GOP-Campaign/id-09e26ae63e9e44efb14a376116e9aa44

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herbert - Save Some Cash With These Helpful Home Improvement ...

[unable to retrieve full-text content]Read through this document for some tips about home improvement with feng shui. Cooking area. Talk to neighbors and search for signs of new construction prior to moving in to a new neighborhood. You don?t desire to wind ...

Source: http://tufyg.livejournal.com/17610.html

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Nano-oils keep the electronic devices really cool

ScienceDaily (Feb. 1, 2012) ? Rice University scientists have created a nano-infused oil that could greatly enhance the ability of devices as large as electrical transformers and as small as microelectronic components to shed excess heat.

Research in the lab of Rice materials scientist Pulickel Ajayan, which appears in the American Chemical Society journal ACS Nano, could raise the efficiency of such transformer oils by as much as 80 percent in a way that is both cost-effective and environmentally friendly.

The Rice team headed by lead authors Jaime Taha-Tijerina, a graduate student, and postdoctoral researcher Tharangattu Narayanan focused their efforts on transformers for energy systems. Transformers are filled with mineral oils that cool and insulate the windings inside, which must remain separated from each other to keep voltage from leaking or shorting.

The researchers discovered that a very tiny amount of hexagonal boron nitride (h-BN) particles, two-dimensional cousins to carbon-based graphene, suspended in standard transformer oils are highly efficient at removing heat from a system.

"We don't need a large amount of h-BN," Narayanan said. "We found that 0.1 weight percentage of h-BN in transformer oil enhances it by nearly 80 percent."

"And at 0.01 weight percentage, the enhancement was around 9 percent," Taha-Tijerina said. "Even with a very low amount of material, we can enhance the fluids without compromising the electrically insulating properties."

Taha-Tijerina, who was employed by a transformer manufacturer in Mexico before coming to Rice, said others working on similar compounds are experimenting with particles of alumina, copper oxide and titanium oxide, but none of the compounds has the combination of qualities exhibited by h-BN.

Narayanan said the h-BN particles, about 600 nanometers wide and up to five atomic layers thick, disperse well in oil and, unlike highly conductive graphene, are highly resistant to electricity. With help from co-author Matteo Pasquali, a Rice professor of chemical and biomolecular engineering and of chemistry, the team determined that the oil's viscosity -- another important quality -- is minimally affected by the presence of the nanoparticle fillers.

"Our research shows that with new materials and innovative approaches, we can add enormous value to applications that exist today in industry," Ajayan, Rice's Benjamin M. and Mary Greenwood Anderson Professor in Mechanical Engineering and Materials Science and of chemistry. "Thermal management is a big issue in industry, but the right choice of materials is important; for transformer cooling, one needs dispersants in oils that take heat away, yet remain electrically insulating. Moreover, the two-dimensional nature of the fillers keeps them stable in oils without settling down for long periods of time."

Co-authors are Guanhui Gao, a visiting scholar in Ajayan's lab; senior Matthew Rohde; and graduate student Dmitri Tsentalovich, all of Rice.

Support for the research came from Prolec GE Internacional, Monterrey, Mexico; the National Council of Science and Technology, Mexico; Nanoholdings LLC; and the MURI program on novel, free-standing 2-D crystalline materials focusing on atomic layers of nitrides, oxides and sulfides, by the Army Research Office.

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Journal Reference:

1. Jaime Taha-Tijerina, Tharangattu N. Narayanan, Guanhui Gao, Matthew Rohde, Dmitri A. Tsentalovich, Matteo Pasquali, Pulickel M. Ajayan. Electrically Insulating Thermal Nano-Oils Using 2D Fillers. ACS Nano, 2012; : 120127124801003 DOI: 10.1021/nn203862p

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/QAdfe2oeJXY/120201140038.htm

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Video: Herb's Rant on 'Farce' Conference Calls

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Source: http://video.msnbc.msn.com/cnbc/46195924/

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